american board gynecology & obstetric mcq

1. The most frequent location of breast cancer is ?
   Upper outer quadrant
   Upper inner quadrant
   Lower outer quadrant
   Lower inner quadrant
   Subareolar location
2. All of the following statements about ductal carcinoma in situ are true except?
   Typically occurs in premenopausal women
   May appear as a palpable mass or a mammographic abnormality
   Associated with an increased risk of invasive breast cancer in the affected breast
   May be treated with lumpectomy and radiotherapy
   May be treated with total mastectomy
3. Which of the following are true about the use of tamoxifen trial in the prevention of breast cancer as sponsored by the NSABP?
   Tamoxifen or placebo was given to women with an increased risk of breast cancer
   Use of tamoxifen was associated with increased risk of cataracts, strokes and pulmonary emboli
   Use of tamoxifen reduced the risk of in situ breast carcinoma
   Use of tamoxifen reduced the risk of breast cancer by reducing the incidence of tumors that were estrogen receptor positive
   All of the above
4. Which of the following is the most important prognostic factor in the survival of patients with breast cancer?
   Tumor size
   Hormone receptor status
   Status of the axillary lymph nodes
   Patient age
   Overexpression of Her-2-neu

5. Most frequent cause of bloody nipple discharge without an associated mass by examination?
   Ductal ectasia
   Intraductal papilloma
   Breast cancer
   Ductal carcinoma in situ
   Phylloides tumor
6. A 24 year old woman presents with an isolated 1.5 cm breast mass. The nature of the mass is unclear at the time of examination. Which of the following is the most reasonable next step ?
   Mammography
   MRI
   Ultrasound of the mass
   Open biopsy
   Mammotome Biopsy
7. Which of the following statements are not true about breast cancer in patients with BRCA germline mutations?
   Most breast cancers in BRCA1 patients are estrogen receptor (ER) positive
   At least 50% arise in women less than the age of 50
   Prophylactic adnexectomy reduces the risk of breast cancer
   BRCA 1 and BRCA 1 germline mutations account for most hereditary breast cancers
   Prophylactic mastectmoy diminishes the risk of breast cancer in patients with BRCA 1 and 2 germline mutations
8. A marker of increased risk of invasive breast cancer in either breast?
   Ductal carcinoma in situ
   Paget's disease
   Lobular carcinoma in situ
   Ductal ectasia
   Intraductal papilloma